May 11, 2022

Uses, dosage, side effects, cost, etc.

Myfembree can cause mild or severe side effects. The following lists contain some of the main side effects that can occur when taking Myfembree. These lists do not include all possible side effects.

For more information about the possible side effects of Myfembree, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be worrying or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA of a side effect you have had with Myfembree, you can do so via MedWatch.

Mild side effects

Mild side effects * of Myfembree may include:

Most of these side effects can go away within a few days to a few weeks. But if they get worse or don’t go away, talk to your doctor or pharmacist.

* This is a partial list of mild side effects of Myfembree. To find out more about other mild side effects, talk to your doctor or pharmacist, or refer to Myfembree prescribing information.
† For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from Myfembree are not common, but they can happen. Call your doctor immediately if you experience serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or if you think you have a medical emergency.

Serious side effects and their symptoms can include:

  • Prolapse or expulsion of uterine fibroids (conditions that occur when fibroids, or parts of them, come out through the vagina). Symptoms may include:
  • Increased blood pressure. This side effect usually does not cause symptoms, but severe increases in blood pressure can cause:
  • Changes in mood or behavior. Symptoms may include:
    • depression (such as prolonged sadness and loss of interest in favorite activities)
  • Liver or gallbladder problems. Symptoms may include:
    • pain in the upper right abdomen
    • jaundice (yellowing of your skin and the whites of your eyes)
  • Increased blood sugar level. Slight increases should not cause symptoms, but severe increases can cause:
    • be thirstier than usual
  • Increased levels of fats in your blood, such as cholesterol or triglycerides. This side effect does not cause symptoms, but it can be discovered during blood tests.
  • Blood clots and blood vessel disorders. * †
  • Bone loss. *
  • Allergic reaction.*

* For more information about this side effect, see “Side effect details” below.
?? Myfembree has a framed warning for this side effect. A boxed warning is the FDA’s most serious warning. It alerts doctors and patients to the effects of drugs that can be dangerous.

Details of side effects

Here are some details about some side effects that this medicine can cause.

Blood clots and blood vessel disorders

Myfembree has a framed warning In regards to blood clots and blood vessel disorders. A boxed warning is the FDA’s most serious warning. It alerts doctors and patients to the effects of drugs that can be dangerous.

Two of the active ingredients in Myfembree are hormones. Estradiol is a type of estrogen and norethindrone is a type of progestin (a synthetic form of progesterone). Medicines that contain these hormones are known to cause an increased risk of blood clots and serious cardiovascular problems. “Cardiovascular” refers to the heart and blood vessels.

In rare cases, Myfembree can cause blood clots. * Specific types of blood clots that can occur include deep vein thrombosis (DVT) and pulmonary embolism (PE). Blood clots can cause serious cardiovascular problems such as a heart attack or stroke.

Some people may have an increased risk of developing blood clots and related cardiovascular problems. For this reason, doctors usually will not prescribe Myfembree if you have certain risk factors for these conditions. Risk factors include:

Another risk factor is smoking and being over 35.

* For more information on how often this side effect occurred in clinical studies, see Myfembree prescribing information.

Symptoms of blood clots

You should call your doctor or see a doctor immediately if you have symptoms of a blood clot. Symptoms of DVT and PE can vary, but can include:

  • pain or pressure in the chest, arm, or leg
  • pain, warmth, or swelling in your arm or leg
  • difficulty in breathing

If you have any questions about the risk of blood clots forming when taking Myfembree, talk to your doctor.

Bone loss

Bone mineral density describes the strength of bones. Loss of bone mineral density can happen with Myfembree. Specifically, bone loss in the lower back has been reported in some people who have taken the drug for up to 1 year in Clinical studies. *

Decreased bone mineral density or bone loss can lead to osteoporosis (weak and brittle bones) and bone fractures. But it is not known whether taking Myfembree further increases your risk of future fractures.

It is not possible to reverse the bone loss caused by Myfembree by stopping treatment with the medicine. Because of this risk of long-term side effects, your doctor will likely prescribe Myfembree for up to 24 months.

Before and during treatment with Myfembree, your doctor may order a bone mineral density test called a DEXA scan. This test checks the strength of your bones.

To help prevent bone loss, your doctor may recommend that you take calcium and vitamin D supplements. Calcium helps strengthen bones, and vitamin D helps your body absorb calcium. If you have any questions about your risk of bone loss with Myfembree, talk to your doctor.

* For more information on how often this side effect occurred in clinical studies, see Myfembree prescribing information.

Hair loss

Hair loss is one of the most common side effects of taking Myfembree. Hair loss and thinning hair have been reported as common side effects during drug administration. Clinical studies. *

In studies, some people have described their hair loss as moderate. Most people continued to take the medicine despite this side effect.

No specific pattern of hair loss has been reported with treatment with Myfembree. It is not yet known whether this side effect can be reversed by stopping treatment with the drug.

If you’re concerned about hair loss with Myfembree, talk to your doctor. They will help you consider the pros and cons. If your heavy period caused by uterine fibroids is severe, the benefit of taking this medication may outweigh your risk of hair loss or thinning. Your doctor may also suggest ways to help prevent or reduce hair loss.

* For more information on how often this side effect occurred in clinical studies, see Myfembree prescribing information.

Allergic reaction

As with most medicines, some people may have an allergic reaction after taking Myfembree. It is not clear how often allergic reactions have occurred during the Clinical studies.

Symptoms of a mild allergic reaction can include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under the skin, usually on the eyelids, lips, hands or feet
  • swelling of the tongue, mouth or throat
  • difficulty in breathing

Call your doctor right away if you have an allergic reaction to Myfembree, as the reaction could get serious. Call 911 or your local emergency number if your symptoms are life-threatening or if you think you have a medical emergency.


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