May 11, 2022

Alternatives, dosage, side effects and more

Like most medicines, Toujeo can cause mild or serious side effects. The lists below describe some of the more common side effects of Toujeo. These lists do not include all possible side effects.

Keep in mind that the side effects of a drug may depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Toujeo. They may also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects Toujeo can cause. To find out more about other mild side effects, talk to your doctor or pharmacist or read the prescribing information.

The mild side effects of Toujeo that have been reported include:

  • a cold
  • upper respiratory tract infection (such as a sinus infection)
  • injection site reaction
  • lipodystrophy or localized skin amyloidosis (skin conditions that cause stinging, thickening, or bumps in the skin around your injection site)
  • itching
  • edema (fluid build-up in the body)
  • eruption*
  • mild hypoglycemia (low blood sugar) *
  • weight gain*

The mild side effects of many medications can go away within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects of Toujeo can occur, but they are not common. If you experience serious side effects from Toujeo, call your doctor immediately. But if you think you have a medical emergency, you should call 911 or your local emergency number.

Serious side effects of Toujeo that have been reported include:

* For more information on this side effect, see the “Side effects overview” section below.

Focus on side effects

Find out more about some of the side effects of Toujeo.

Weight gain

When you take insulin, including Toujeo, you may gain weight. Weight gain may occur when you start treatment with Toujeo because the medicine may make you urinate less than before.

Diabetes makes you urinate more often than usual. When your blood sugar is too high, your body gets rid of excess sugar through urine. Urinating frequently means that you are losing more water from your body than usual. This decreases your “water weight”.

When you take Toujeo and your diabetes is well managed, you will usually stop urinating as much. This can cause you to gain weight because your body will not get rid of as much water.

Toujeo can also cause weight gain as it affects your metabolism. Insulin decreases the breakdown of fats and proteins in your body. It also activates the production of certain fats and proteins. It can make you gain weight.

What could help

Healthy eating and regular physical activity can help prevent weight gain. It can also help you manage your blood sugar.

If you’re worried about gaining weight, talk to your doctor. They can help you reach or maintain a weight that is right for you.


A rash may appear where you inject Toujeo. A rash can be a symptom of an allergic reaction or a reaction at the injection site.

Reactions at the injection site are usually mild and may cause other symptoms, such as redness, pain, and bruising.

If you get a rash all over your body or most of your body, it could be a symptom of a serious allergic reaction. Other symptoms of an allergic reaction may include difficulty breathing, rapid heartbeat, or sweating. See “Allergic reaction” below for more details.

What could help

If you think you are having an allergic reaction to Toujeo, contact your doctor immediately. Get emergency medical help if you have difficulty breathing, a fast heartbeat, or unusual or excessive sweating.

A reaction at the injection site is usually mild and goes away with time. If you have a rash that does not go away with time, talk to your doctor or pharmacist. They may suggest other injection techniques to help prevent rashes at the injection site.


Hypoglycemia (low blood sugar) is the most common side effect of Toujeo. If your blood sugar drops too low, it can be life threatening.

Your doctor will tell you which symptoms of hypoglycaemia to watch out for. Some symptoms include:

  • feeling shaky, nervous, anxious, or irritable
  • sweat
  • headache and confusion
  • feeling dizzy or dizzy
  • nausea
  • sight problems
  • balance problems

If your blood sugar gets very low or stays low for a long time, you may have more serious symptoms. These can include fainting and seizures. Rarely, severe hypoglycemia can lead to death.

What could help

To help prevent hypoglycemia, check your medication labels to make sure you are injecting the correct amount of insulin for each dose. If you take different types of insulin, make sure you are taking the right insulin at the right time. Your doctor will explain to you how to monitor your blood sugar and manage hypoglycemia if it occurs.

If you have low blood sugar, you should eat something sweet. The 15-15 rule is useful for remembering how much sugar to take: you will take 15 grams (g) of sugar and check your blood sugar 15 minutes later.

Examples of 15 g of sugar:

  • glucose tablets or gels
  • half a cup (4 ounces) of juice or regular soda (non-diet)
  • 1 tbsp (tbsp) sugar, honey or corn syrup
  • hard candy, jelly beans, or gumballs

Allergic reaction

Some people may have an allergic reaction to Toujeo.

Symptoms of a mild allergic reaction can include:

  • eruption
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include a rash all over the body and swelling under the skin (usually on the eyelids, lips, hands, or feet). They can also include swelling of the tongue, mouth, or throat, which can cause difficulty in breathing.

Call your doctor at once if you have an allergic reaction to Toujeo. But if you think you have a medical emergency, call 911 or your local emergency number.

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