May 11, 2022

Before and after use, cost, side effects, uses, etc.

Tepezza can cause mild or severe side effects. The following lists contain some of the main side effects that may occur during treatment with Tepezza. These lists do not include all possible side effects.

For more information about the possible side effects of Tepezza, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be concerning or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA of a side effect you have had with Tepezza, you can do so via MedWatch.

Mild side effects

Mild side effects* of Tepezza may include:

  • nausea
  • hair loss
  • fatigue (lack of energy) or weakness
  • taste changes
  • headache
  • dry skin
  • muscle spasms†
  • hearing problems, such as hearing loss‡
  • diarrhea

Most of these side effects may disappear during or after treatment with Tepezza. But if they get worse or don’t go away, talk to your doctor or pharmacist.

*To learn more about the mild side effects of Tepezza, talk to your doctor or pharmacist or see the Tepezza page. prescribing information.
† For more information on this side effect, see “Details of side effects” below.
‡ In Clinical studies from Tepezza, hearing side effects resolved in most people or occurred in people who had hearing problems in the past.

Serious side effects

Serious side effects of Tepezza can occur. Call your doctor right away if you experience any serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Serious side effects* may include:

* For more information on these side effects, see ‘Details of side effects’ below.

Details of side effects

Here are some details about some side effects that this drug can cause.

Infusion reactions

During treatment with Tepezza you may experience reactions related to intravenous (IV) infusions drug. (With an IV infusion, the medicine is delivered into your vein over a period of time.)

Infusion reactions are not common with Tepezza. However, they are possible.

Infusion reactions that may occur with Tepezza may lead to:

A healthcare professional will give you Tepezza infusions at a hospital or infusion centre. Each infusion will be given over a period of 60 to 90 minutes. You will be monitored during this time for the infusion reaction.

It is possible to have symptoms of an infusion reaction at any time during a Tepezza infusion. Or, these reactions may start within 1.5 hours of your infusion.

Management of infusion reactions

Tell your healthcare professional if you have any new or unusual symptoms during or after Tepezza infusions.

If you have a mild to moderate infusion reaction, your healthcare professional will manage your symptoms with a corticosteroid or antihistamine. And they can slow down or pause your Tepezza infusion to help manage your symptoms.

To prevent reactions to future infusions, your healthcare professional may:

  • give you certain medicines before you start your Tepezza infusions
  • infuse Tepezza at a slower rate than usual

However, if you have a serious infusion reaction with Tepezza, your doctor may stop your treatment with the medicine.

High blood sugar levels

Tepezza can raise your blood sugar or cause hyperglycemia. With hyperglycemia, your blood sugar level is too high.

Increased blood sugar is a common side effect of Tepezza. However, your risk may be higher if you had diabetes or prediabetes before starting Tepezza.

You may not notice any symptoms of high blood sugar. So, during treatment with Tepezza, your doctor will order tests to check your blood sugar levels. Your doctor will check your levels even if you do not have diabetes or prediabetes before starting the medication.

However, if you experience certain symptoms during treatment with Tepezza, talk to your doctor. Symptoms that may indicate hyperglycemia include:

  • feeling of excessive thirst
  • fatigue (lack of energy)
  • blurred vision
  • urinate more than usual
  • fruity breath

If you have diabetes, your doctor will ensure that your blood sugar is controlled before starting Tepezza. And during treatment, they can adjust your diabetes treatment plan to help manage levels.

If you do not have diabetes, but your blood sugar levels are high with Tepezza, your doctor may suggest ways to manage the levels. This could include suggesting certain diet changes or combining diet changes with medication.

Muscle spasms

During treatment with Tepezza you may have muscle spasms. Indeed, during Clinical studieswas the most common side effect of the drug.

A muscle spasm is a sudden cramp or contraction in one or more of your muscles. Muscle spasms can be painful or cause other bothersome symptoms, such as weakness.

If you have mild muscle spasms that bother you, talk to your doctor. They may prescribe a muscle relaxant to help reduce spasms. Or, your doctor may suggest non-drug treatments, such as massage.

If you have moderate to severe muscle spasms, see your doctor right away.

Also tell your doctor if you have muscle spasms with diarrhea. Diarrhea is a common side effect of Tepezza which can cause dehydration (low fluid level in your body). And dehydration is a common cause of muscle spasms.

Allergic reaction

As with most medicines, some people may have an allergic reaction following treatment with Tepezza.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • flushing (warmth, swelling, redness or discoloration of the skin)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Tepezza, as the reaction could become serious. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.


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