May 11, 2022

Costs, uses, side effects and more

As with most medicines, Simponi and Simponi Aria can cause mild or severe side effects. The lists below describe some of the more common side effects that Simponi and Simponi Aria can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Simponi and Simponi Aria. They can also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Simponi and Simponi Aria can cause. To learn about other mild side effects, talk to your doctor or pharmacist, or read Simponi and Simponi Aria prescribing information.

Mild Simponi side effects that have been reported include:

Mild Simponi Aria side effects that have been reported include:

  • mild infection, such as a cold or the flu
  • infusion reaction, which may occur during or shortly after your Simponi Aria infusion, such as:

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects from Simponi and Simponi Aria can occur, but they are not common. If you experience serious side effects with Simponi or Simponi Aria, call your doctor right away. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious side effects of Simponi and Simponi Aria that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn about some of the side effects Simponi and Simponi Aria can cause.

Boxed warnings

Simponi and Simponi Aria have boxed warnings. A framed warning is a serious warning from the Food and Drug Administration (FDA). Boxed drug warnings are described below.

Cancer. Simponi and the Simponi area may increase your risk of certain cancers. These include leukemia, lymphoma and skin cancer. But this side effect was rare in studies of Simponi and Simponi Aria.

In some cases, cancer caused by Simponi or Simponi Aria can be fatal. Talk to your doctor to learn more about your risk.

While taking Simponi or Simponi Aria, watch for symptoms of cancer. Keep in mind that symptoms can vary depending on the type of cancer. Symptoms of cancer can include:

  • fever
  • weightloss
  • bruising or bleeding more easily than usual
  • fatigue (low energy)

Serious infections. Simponi and Simponi Area may increase your risk of serious infections. But this side effect was rare in studies of Simponi and Simponi Aria.

Some Simponi and Simponi Aria infections can be serious enough to require a hospital stay for treatment. In rare cases, infections caused by these drugs can be fatal. Talk to your doctor to learn more about your risk.

Serious infections that can occur with Simponi and Simponi Aria can be caused by bacteria, fungi or viruses. Examples include pneumonia and cellulitis (a painful skin infection).

Symptoms may depend on the specific infection you have, but may include:

Simponi and the Simponi area can also cause reactivation of tuberculosis (TB) or hepatitis B virus (HBV) in people who have had these conditions in the past.

Your risk of serious Simponi and Simponi infections may be higher if you:

  • are 65 or older
  • recently traveled to areas with high rates of tuberculosis or other infections
  • have infections that last a long time or keep coming back
  • have certain health conditions that increase your risk of infection, such as diabetes or HIV
  • taking certain medications, including:

What might help

If you are concerned about your risk of cancer or serious infections with Simponi or Simponi Aria, talk to your doctor.

If you have symptoms of cancer or infection, tell your doctor immediately. They can determine if it is safe for you to continue treatment.

Your doctor may test you for tuberculosis and HBV before and during your treatment with Simponi or Simponi Aria. If you have either of these conditions, your doctor may want to treat it before starting any of these medications. And they will continue to monitor you for TB and HBV during your treatment.

High blood pressure

Some people may get high blood pressure with Simponi or Simponi Aria. But this was not among the most frequently reported side effects in studies of Simponi and Simponi Aria.

High blood pressure usually causes no symptoms unless it is severe. Symptoms that can occur with severe high blood pressure include dizziness and flushing (temporary warmth, redness, or deepening of skin color).

What might help

If you have symptoms of severe high blood pressure with Simponi or the Simponi area, tell your doctor immediately. But if your symptoms seem life-threatening, call 911 or your local emergency number right away.

Your doctor will probably check your blood pressure while you are receiving treatment with Simponi and Simponi Aria. They may also recommend that you monitor your own blood pressure with a home monitor. Your doctor can show you how to use a home monitor and tell you how often to check your blood pressure.

If you are concerned about your risk of high blood pressure with Simponi or Simponi Aria, talk to your doctor.

Allergic reaction

Some people may have an allergic reaction to Simponi and Simponi Aria. Allergic reaction has not been reported in studies of Simponi and Simponi Ariabut it has been reported since the drugs became available.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Simponi and Simponi Aria. But if you think you have a medical emergency, call 911 or your local emergency number.


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