May 11, 2022

Dosage, side effects, uses, operation, cost, etc.

Amaryl can cause mild or severe side effects. The following lists contain some of the main side effects that can occur when taking this medication. These lists do not include all possible side effects.

For more information about the possible side effects of Amaryl, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be concerning or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA of a side effect you have had with Amaryl, you can do so via MedWatch.

Mild side effects

Mild side effects* of Amaryl may include:

Most of these side effects may disappear within a few days to a few weeks. But if they get worse or don’t go away, talk to your doctor or pharmacist.

*This is a partial list of mild Amaryl side effects. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Amaryl package leaflet. prescribing information.

Serious side effects

Serious Amaryl side effects are not common, but they can occur. Call your doctor right away if you experience any serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Serious side effects and their symptoms may include:

* For more information on this side effect, see ‘Details of side effects’ below.

Details of side effects

Here are some details about some side effects that this drug can cause. For details on how often these side effects occurred in clinical trials, see Amaryl’s prescribing information.

Hypoglycemia

Hypoglycemia (low blood sugar) is a common side effect of Amaryl. The drug is prescribed to lower blood sugar in adults with type 2 diabetes. But sometimes Amaryl can cause your blood sugar levels to drop too low.

According to American Diabetes Association (ADA)hypoglycemia occurs when your blood sugar drops to 70 milligrams/deciliter (mg/dL) or lower.

Before starting treatment with Amaryl, your doctor will discuss with you what to do when you first notice symptoms of low blood sugar. Early symptoms of low blood sugar may include feeling anxious, dizzy, shaking, sweating, or clammy.

Treat hypoglycemia

The ADA recommends the “15-15” rule for managing hypoglycemia. This involves taking a 15 gram (g) serving of carbs and then checking your blood sugar after 15 minutes. If your level is still below 70 mg/dL, take another serving of carbs. You should repeat this process until your blood sugar level returns to normal.

Examples of a 15g serving of carbs are 4 ounces of fruit juice and non-diet soda. Another example is 1 tablespoon of honey or sugar. You can also eat glucose tablets or hard candy. However, check the product label to see how much you will need to consume per 15g. Keep in mind that diet soda or diet or sugar-free candy will not treat hypoglycemia.

Very low blood sugar explained

If your blood sugar continues to drop, severe hypoglycaemia (very low blood sugar) may occur. This is a medical emergency and can be fatal. If you develop any of the following symptoms, you or a caregiver should seek emergency help immediately:

What can increase your risk

Certain factors may increase the risk of mild or severe hypoglycemia while taking Amaryl. Here are some examples :

  • skipping meals or eating fewer calories than usual
  • burning more calories than usual due to exercising more intensely or for longer than usual
  • drinking alcohol
  • taking certain medications, such as beta-blockers, that make early symptoms of low blood sugar less noticeable than usual
  • use of insulin or other diabetes medications in combination with Amaryl
  • having nausea and vomiting due to illness
  • be 65 or older

If any of these factors apply to you, your doctor may adjust your dose of Amaryl. Keep in mind that you should monitor your blood sugar closely often while taking the medication.

If you have any questions about managing hypoglycemia with Amaryl, talk to your doctor.

Weight gain

Weight gain is a common side effect of Amaryl. In clinical tests, weight gain was more common in people who took higher doses of the drug (4 mg or 8 mg). Weight gain was generally mild.

Keep in mind that Amaryl is meant to be used in combination with regular physical activity and a balanced diet. These actions can help prevent or reduce weight gain. If you have any questions about managing your weight while taking Amaryl, talk to your doctor.

Allergic reaction

As with most medications, some people may have an allergic reaction after taking Amaryl.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Amaryl, as the reaction could become severe. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.


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