August 13, 2022

Side effects, cost, uses and more

Like most medicines, Orilissa can cause mild or serious side effects. The lists below describe some of the more common side effects that Orilissa can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a drug may depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Orilissa. They may also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Orilissa can cause. To find out more about other mild side effects, talk to your doctor or pharmacist, or read the Orilissa guide. medication guide.

The mild side effects of Orilissa that have been reported include:

The mild side effects of many medications can go away within days or weeks. But if they become bothersome, talk to your doctor or pharmacist.

* For more information on this side effect, see the “Side effects overview” section below.

Serious side effects

Serious side effects of Orilissa can occur, but they are not common. If you experience serious side effects from Orilissa, call your doctor immediately. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious Orilissa side effects that have been reported include:

* For more information on this side effect, see the “Side effects overview” section below.

Suicide prevention

If you think someone is at immediate risk of harming themselves or someone else:

  • Call 911 or your local emergency number.
  • Stay with the person until help arrives.
  • Remove any guns, knives, drugs, or other items that may cause damage.
  • Listen, but don’t judge, argue, threaten, or yell.

If you or someone you know is planning to kill yourself, get help from a hotline or suicide prevention hotline. Try the National Suicide Prevention Lifeline at 800-273-8255.

Focus on side effects

Learn more about some of the side effects Orilissa can cause.

Stopped periods

As a side effect, taking Orilissa may cause your period to stop. You may also bleed for less or less time during your period.

This side effect was more common than others reported by people who took the medicine in studies. But, it is important to note that most people who take Orilissa have not stopped having their period. People taking a higher dose of Orilissa were more likely to have this side effect.

What could help

Talk to your doctor if you have stopped your period and it bothers you while you are taking Orilissa. They can discuss your treatment plan with you and suggest the best way to treat your condition.

Keep in mind that the period changes caused by Orilissa can make it difficult to tell if you are pregnant. So, if your period stops while you are taking Orilissa, watch for other signs of pregnancy, such as nausea and breast tenderness. This medicine is not safe to take during pregnancy. (For more information, see “Pregnancy and breast-feeding” under “What to consider before taking Orilissa?” Below).

Weight gain

Although it is not common, you may gain weight while taking Orilissa. This has been reported by people taking the medicine in studies, but it was rare.

What could help

If you are worried or have questions about your weight, talk to your doctor. They can recommend ways to maintain a healthy weight for you.

Bone loss

Orilissa is known to cause bone loss. In studies, people who took the medicine lost their bone mineral density (BMD). The degree of BMD loss varied, but was severe in some people. (BMD indicates the strength of your bones.)

Taking a higher dose of Orilissa increases your risk of bone loss. And the longer you take Orilissa, the greater the risk.

It is not known whether the bone loss caused by Orilissa is completely reversible even if you stop taking the medicine. And it is not known whether this bone loss increases the risk of fractures with age.

What could help

Due to the risk of bone loss, you should not take Orilissa for more than 24 months. But if you take Orilissa twice a day or if you have liver problems, you should not take the medicine for more than 6 months.

While you are taking Orilissa, your healthcare professional may recommend that you take extra vitamin D and calcium. They may also suggest other ways to support your bone health.

Before you start taking Orilissa tell your doctor if you have ever broken a bone. You should also tell them about any medications you are taking, so they can see if they are causing bone loss. If you’ve ever broken a bone or are taking another medicine that causes bone loss, your doctor may order an x-ray to check your bone health.

You should not take Orilissa if you have osteoporosis. Instead, ask your doctor about other treatment options for your condition.

Allergic reaction

Some people may have an allergic reaction to Orilissa.

Symptoms of a mild allergic reaction can include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include swelling under the skin, usually in the eyelids, lips, hands, or feet. They can also include swelling of the tongue, mouth, or throat, which can cause difficulty in breathing.

Call your doctor at once if you have an allergic reaction to Orilissa. But if you think you have a medical emergency, call 911 or your local emergency number.


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