June 23, 2022

Side Effects, Cost, Uses, Dosage & More

Like most medicines, Nexlizet can cause mild to severe side effects. The lists below describe some of the most common, but they do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Nexlizet. They can also suggest ways to help reduce side effects.

Mild side effects

Below is a list of some of the mild side effects that Nexlizet can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Nexlizet package leaflet. prescribing information.

Mild Nexlizet side effects that have been reported include:

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

*For more information on this side effect, see the “Side Effects Focus” section below.

Serious side effects

Serious side effects from Nexlizet can occur, but they are not common. If you have serious side effects from Nexlizet, call your doctor right away. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious Nexlizet side effects that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some of the side effects Nexlizet can cause.

Muscle cramps

Some people may have muscle cramps while taking Nexlizet. These are sudden muscle spasms that you cannot control. Affected muscles may feel tight, hard, or sore. Most people who took Nexlizet in studies did not have this side effect. But some people have had to stop the drug due to severe muscle cramps, although this is rare.

What might help

Muscle cramps usually go away on their own within seconds to minutes. Here are some tips to try if you have a muscle cramp:

  • Stretch the affected area of ​​your body.
  • Gently massage the tense or painful area.
  • Move. For example, if a leg cramp occurs while you are in bed, it may help to get up and walk around.

Staying hydrated can also help prevent muscle cramps. Be sure to drink plenty of fluids each day, especially if you exercise in hot weather.

Talk with your doctor if muscle cramps become severe while taking Nexlizet. They may recommend a different treatment option for your condition.

Stomach ache

Some people may have stomach pain while taking Nexlizet. While most people who take the drug in studies did not have this side effect, some reported pain or discomfort in their upper or lower abdomen.

What might help

If you have stomach pains while taking Nexlizet, they should go away with continued treatment. Some people find that taking the drug with food helps prevent or lessen this side effect. (Nexlizet can be taken with or without food.)

If this side effect does not go away or gets worse, talk to your doctor. They may want to examine you for other causes of abdominal pain. Or they may prescribe you a different cholesterol-lowering medicine instead of Nexlizet.

tendon problems

Nexlizet contains the active ingredient bempedoic acid. This ingredient may increase the risk of tendon problems. (Tendons are connective tissues that attach muscles to bones.)

Pain or swelling may occur if the tendons rupture, tear, or become inflamed. In studies, tendon rupture has occurred in the shoulders, biceps, or Achilles tendons of some people.

Certain factors may further increase the risk of tendon problems with this medication, including:

  • having had a tendon rupture or injury in the past
  • be 60 or older
  • have kidney failure
  • taking a corticosteroid (such as prednisone) or a fluoroquinolone antibiotic (such as ciprofloxacin)

This side effect was not specifically reported in the Nexlizet study. studies. But this happened rarely in studies looking only at bempedoic acid, one of the active drugs in Nexlizet. (An active ingredient is what makes a drug work.)

What might help

Before starting Nexlizet, be sure to tell your doctor if any of the above apply to you. They may prescribe a different treatment for high cholesterol that does not contain bempedoic acid. Or if you need to take a short course of a steroid or a fluoroquinolone antibioticthey may ask you to temporarily suspend processing by Nexlizet.

If you experience pain or swelling anywhere in your body, rest the affected area and notify your doctor immediately. They will help you identify the cause of your symptoms. If they confirm that you have a tendon injury, they will probably stop taking Nexlizet.

Allergic reaction

Some people may have an allergic reaction to Nexlizet. Allergic reactions have been reported in people taking ezetimibe, one of the active ingredients in Nexlizet.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms can include swelling under the skin, usually in the eyelids, lips, hands, or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Nexlizet. But if you think you have a medical emergency, call 911 or your local emergency number.


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