May 11, 2022

Side effects, cost, uses, interactions, dosage, etc.

Tagrisso can cause mild to severe side effects. The following lists contain some of the main side effects that can occur when taking Tagrisso. These lists do not include all possible side effects.

For more information about the possible side effects of Tagrisso, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be concerning or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA about an adverse reaction you have had with Tagrisso, you can do so via MedWatch.

Mild side effects

Mild side effects* of Tagrisso may include:

Most of these side effects may disappear within a few days or weeks. However, if they get worse or don’t go away, talk to your doctor or pharmacist.

*This is a partial list of mild Tagrisso side effects. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Tagrisso package leaflet. prescribing information.
† For more information on this side effect, see “Details of side effects” below.

Serious side effects

Serious side effects of Tagrisso can occur. Call your doctor right away if you experience any serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Serious side effects and their symptoms may include:

* For more information on this side effect, see ‘Details of side effects’ below.

Details of side effects

Here are some details about some side effects that this drug can cause.

Rash and other skin problems

Some people may develop a mild or severe skin rash while taking Tagrisso. It can also cause other skin problems listed below.

In clinical tests, mild skin problems were common with Tagrisso. Serious skin rashes were reported less frequently. To learn more about how often this side effect occurred in clinical trials, see the drug’s fact sheet. prescribing information.

Examples of mild skin problems reported with Tagrisso include:

The following are examples of serious skin rashes reported with Tagrisso and their symptoms:

  • Stevens-Johnson syndrome (generalized painful rash affecting the skin and mucous membranes [moist tissue lining your mouth, throat, eyes, nose, and genitals]). Symptoms can include:
    • severe blisters followed by peeling of the skin and mucous membranes
  • Erythema multiforme (skin reaction caused by an immune response to a viral infection). Symptoms can include:
    • raised red, purple, or discolored rash affecting the skin and mucous membranes
    • ring-shaped spots that look like targets
    • sore mouth, throat and eyes
  • Cutaneous vasculitis (inflammation of the blood vessels in your skin). Symptoms can include:
    • red, purple, or dark spots on the forearms, lower legs, or buttocks that last longer than 24 hours
    • large hives or bruises on your body that last longer than 24 hours

If you have a mild but bothersome skin problem while taking Tagrisso, talk to your doctor. They can recommend ways to deal with the problem.

Some serious rashes can be life-threatening and require hospital treatment. If you experience symptoms of a severe rash while taking Tagrisso, contact your doctor immediately. Your doctor may recommend that you stop taking Tagrisso while they check the cause of the rash. If your doctor confirms that you have a serious rash, they will ask you to stop taking Tagrisso permanently.

Lung problems, such as pneumonia

Tagrisso can sometimes cause serious lung problems, such as pneumonitis and interstitial lung disease (IP). Pneumonitis is inflammation (irritation and swelling) of the air sacs in your lungs. ILD is an inflammation that causes scar tissue to form in your lungs.

In clinical tests, severe lung problems were not a common side effect of Tagrisso treatment. To learn more about how often this side effect occurred in clinical trials, see the drug’s fact sheet. prescribing information.

Symptoms of serious lung problems can be similar to symptoms of lung cancer. (Tagrisso is used to treat certain types* of non-small cell lung cancer). Symptoms can include:

Severe lung problems can be life threatening.If you have any new or worsening lung symptoms while taking Tagrisso, contact your doctor immediately. Your doctor may recommend that you stop taking Tagrisso while they check the cause of your symptoms. If your doctor confirms that you have pneumonitis or PID, they will ask you to permanently stop taking Tagrisso.

* For more information about the conditions Tagrisso is used to treat, see “Uses of Tagrisso” below.

Hair loss

Some people may experience hair loss or thinning hair while taking Tagrisso. However, hair loss was not a common side effect reported in clinical tests by Tagrisso. To learn more about how often this side effect occurred in clinical trials, see the drug’s fact sheet. prescribing information.

It is important to note that hair loss is a common side effect of other cancer treatments. These include chemotherapy and radiation therapy. Your doctor may prescribe these therapies to treat your lung cancer.

If you have hair loss that bothers you, talk to your doctor. They can recommend ways to help manage this side effect.

Ocular (eye) side effects

Tagrisso can cause an ocular (eye) side effect called keratitis. Keratitis is an inflammation (irritation and swelling) of the cornea (light front layer of your eye).

Keratitis was a rare side effect in clinical tests by Tagrisso. To learn more about how often this side effect occurred in clinical trials, see the drug’s fact sheet. prescribing information.

Symptoms of keratitis can include:

If left untreated, keratitis can lead to the formation of ulcers (sores) or scars on your cornea. This could cause blindness In some cases.

If you experience symptoms of keratitis while taking Tagrisso, contact your doctor immediately. They will likely refer you to an eye doctor. They may recommend that you stop taking Tagrisso while the condition is treated.

ALLERGIC REACTION

As with most medicines, some people may have an allergic reaction after taking Tagrisso.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Tagrisso, as the reaction could become serious. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.


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