May 11, 2022

Side effects, dosage and more

Like most medicines, azulfidine and azulfidine EN tablets can cause mild or severe side effects. The lists below describe some of the more common side effects of Azulfidine and Azulfidine EN tablets. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

For more information on the side effects of these medications, see this article. Your doctor or pharmacist can also tell you more about the potential side effects of Azulfidine and Azulfidine EN-tabs. And they can suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Azulfidine and Azulfidine EN tablets can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the prescribing information for these drugs.

Mild side effects of Azulfidine and Azulfidine EN-tabs that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects of azulfidine and azulfidine EN tablets can occur, but they are not common. If you have serious side effects with either drug, call your doctor right away. But if you think you have a medical emergency, you should call 911 or your local emergency number.

Serious side effects of Azulfidine and Azulfidine EN tablets that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some of the side effects that Azulfidine and Azulfidine EN tablets can cause.

Severe skin reactions

Azulfidine and Azulfidine EN tablets can cause serious skin reactions that can be life-threatening.

It is not known exactly how often these side effects have occurred in studies of these drugs. They are believed to be rare.

These reactions are more frequent during the first month of treatment. But they can occur at any time while taking Azulfidine or Azulfidine EN-tabs.

Severe skin reactions reported with azulfidine and azulfidine EN tablets include:

Symptoms of a severe skin reaction may include:

  • blisters on the eyes, lips, mouth, or skin
  • fever
  • flu-like symptoms
  • rash that continues to get worse
  • reddened or discolored skin
  • severe rash
  • skin burning or pain
  • skin peeling

What might help

Serious skin reactions such as DRESS, SJS, and TEN can be life-threatening and require treatment in hospital. If you think you are having a severe skin reaction, stop taking Azulfidine or Azulfidine EN-tabs and contact your doctor immediately. If your symptoms are life-threatening, seek emergency medical attention immediately. Dial 911 or go to the nearest emergency room.

If your doctor confirms that you have had a serious skin reaction to azulfidine or azulfidine EN tablets, they will ask you to stop taking the medicine. They can discuss other treatment options with you for your condition.

Kidney problems

Although rare, kidney problems can occur following treatment with Azulfidine or Azulfidine EN-tabs. Kidney problems reported by people taking the drugs in studies include nephritis (inflammation of the kidneys) and kidney failure.

Symptoms of kidney problems caused by Azulfidine or Azulfidine EN-tabs may include:

If you already have kidney problems, such as chronic kidney disease, these drugs could make your condition worse.

What might help

Before taking Azulfidine or Azulfidine EN-tabs, tell your doctor if you have kidney problems. The medicine may not be safe for you. Your doctor can discuss other treatment options with you.

While you are taking azulfidine or azulfidine EN tablets, your doctor may order kidney function tests to check your kidney health. These tests can help detect kidney problems before they start causing symptoms.

If you notice symptoms of kidney problems while taking azulfidine or azulfidine EN tablets, contact your doctor immediately. If they confirm that you have kidney problems, they will probably ask you to stop taking azulfidine or azulfidine EN tablets.

Low sperm count and infertility

Low sperm count and infertility have been reported in men* taking azulfidine or azulfidine EN tablets. How many times exactly has this side effect occurred in the studies of these drugs is not known. A low sperm count is one of the most common side effects caused by these drugs. But this side effect also tends to go away once you stop taking the drug.

* In this article, we use the term “male” to refer to the sex assigned to a person at birth. For more information on the difference between sex and gender, check out this article.

What might help

If you are concerned about low sperm count and infertility caused by azulfidine or azulfidine EN tablets, talk to your doctor. Stopping treatment with the drug seems to reverse the low sperm count. Your doctor may also suggest other treatments for your condition, including medications that may not cause sexual side effects.

Allergic reaction

Some people may have an allergic reaction to azulfidine and azulfidine EN tablets. It is not known exactly how often these reactions occurred in studies.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to azulfidine and azulfidine EN tablets. But if you think you have a medical emergency, call 911 or your local emergency number.


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