May 11, 2022

Side Effects, Dosage, Cost, Uses & More

Like most medicines, Xarelto can cause mild or severe side effects. The lists below describe some of the more common side effects that Xarelto can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Xarelto. They can also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Xarelto can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Xarelto package leaflet. prescribing information.

Mild side effects of Xarelto that have been reported in adults include:

  • tiredness (low energy) and tiredness*
  • stomach ache or back pain
  • dizziness
  • insomnia (difficulty falling asleep or staying asleep)
  • itchy feeling
  • muscle spasms (tightness you can’t control)

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects of Xarelto may occur. If you have serious side effects from Xarelto, call your doctor right away. But, if you think you have a medical emergency, you should call 911 or your local emergency number.

Serious side effects of Xarelto that have been reported in adults include:

The most commonly reported adverse reactions in children were:

* For more information on this, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some of the side effects Xarelto can cause.

Boxed warnings

Xarelto has the following framed warningswhich are serious warnings from the Food and Drug Administration (FDA).

Risk of blood clots when stopping Xarelto. Stopping Xarelto without your doctor’s advice may increase your risk of blood clots. Because of this risk, your doctor will probably recommend that you do not stop taking Xarelto without first discussing your treatment plan with them.

Risk of spinal or epidural hematoma after certain spinal injections. Xarelto may increase your spine risk hematoma (accumulation of blood around your spine) or an epidural hematoma (accumulation of blood around your brain). This can happen after spinal or epidural anesthesia or a lumbar puncture.

A hematoma can cause serious problems, such as paralysis (inability to move part of your body). Tell your doctor right away if you have any possible symptoms of a hematoma. These may include sudden back pain, numbness, muscle weakness or tingling, or loss of control of your bladder or bowels.

What might help

Do not stop taking Xarelto without talking to your doctor first. If you need to stop Xarelto, your doctor will probably recommend another medicine to prevent or treat your blood clots.

If you need spinal or epidural injections while taking Xarelto, your doctor may recommend that you schedule it around your dose of Xarelto. If you perform your procedure when the amount of Xarelto in your body is lowest, you have the lowest risk of complications. Your doctor will likely monitor you during your procedure to make sure you don’t have any symptoms of a hematoma.

Tiredness and weariness

You may feel tired (low energy) or tired after taking Xarelto. Although not a commonly reported side effect in studiesit can happen.

What might help

If you feel more tired than usual while taking Xarelto, tell your doctor. They can help determine what is causing your fatigue and how to prevent it from happening.

Side effects in the elderly

If you are 65 or older, you may have an increased risk of certain side effects from Xarelto, such as serious bleeding or blood clots. But Xarelto seems to work just as well in older people as it does in younger people.

What might help

Know the symptoms of bleeding or a blood clot while taking Xarelto. Bruising more easily than usual or having blood in the stool, urine or vomiting are possible signs of bleeding. And a blood clot can cause symptoms such as chest or leg pain, or difficulty breathing.

If you are concerned about your risk of bleeding or clotting with Xarelto, talk to your doctor or pharmacist. They can help you determine if Xarelto is a safe treatment for you.

Allergic reaction

Some people may have an allergic reaction to Xarelto.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Xarelto. But if you think you have a medical emergency, call 911 or your local emergency number.


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