May 11, 2022

Side effects, dosage, uses, etc.

Steglatro can cause mild or serious side effects. The following lists contain some of the main side effects that can occur when taking Steglatro. These lists do not include all possible side effects.

For more information about the possible side effects of Steglatro, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be worrying or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA of a side effect you have had with Steglatro, you can do so via MedWatch.

Mild side effects

Mild side effects * of Steglatro may include:

Most of these side effects can go away within days or weeks. But if they get worse or don’t go away, talk to your doctor or pharmacist.

* This is a partial list of mild side effects of Steglatro. To find out more about other mild side effects, talk to your doctor or pharmacist, or consult Steglatro prescribing information.
† For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from Steglatro are not common, but they can happen. Call your doctor immediately if you experience serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or if you think you have a medical emergency.

Serious side effects and their symptoms can include:

  • Dehydration, which can cause low blood pressure and kidney damage. Symptoms may include:
    • dizziness, especially when changing position, such as sitting down or standing up
    • urinate less than usual
  • Hypoglycaemia (low blood sugar level), when Steglatro is used with insulin or a sulfonylurea medicine, such as glipizide (Glucotrol). Symptoms may include:
  • Increased risk of requiring lower limb amputation (surgical removal of all or part of a leg, foot or toe).
  • Serious urinary tract infections (UTIs), such as pyelonephritis (infection of the kidneys) and urosepsis (a severe response to an infection that started in the urinary tract, bladder or kidneys, which can cause serious problems, including including death). *
  • Fournier’s gangrene (a serious and potentially fatal infection of the perineum, which is the tissue between the genitals and the anus). *
  • Allergic reaction.*
  • Ketoacidosis (high level of acid in the blood). *

* For more information about this side effect, see “Side effect details” below.

Details of side effects

Here are some details about some side effects this medication can cause.

Weightloss

Steglatro increases the amount of sugar your body gets rid of in your urine. It removes calories from your body. As a result, some people may lose weight while taking Steglatro.

For some people with type 2 diabetes, weight loss can be beneficial for their health. This is because it can help lower blood sugar levels, which are increased in people with diabetes. However, if you’re worried about losing weight while taking Steglatro, talk to your doctor.

It is important to note that Steglatro should not be taken for weight loss. It is not approved by the FDA as a weight loss drug, it is only approved to treat type 2 diabetes. Steglatro should only be used as prescribed by your doctor.

Infections

Steglatro increases the amount of sugar in your urine. This can lead to increased growth of bacteria in your urinary tract. It can also lead to increased growth of yeast or bacteria in the genital area.

For this reason, taking Steglatro may increase your risk of developing certain genital or urinary tract infections. These include:

  • genital yeast infection
  • mild urinary tract infections (UTIs)
  • serious urinary tract infections, such as pyelonephritis (infection of the kidneys) and urosepsis (a severe response to an infection that started in the urinary tract, bladder, or kidneys, which can lead to serious problems, including death)
  • Fournier’s gangrene (a serious and life-threatening bacterial infection of the perineum, which is the tissue between the genitals and the anus)

In clinical tests, genital yeast infections and mild urinary tract infections have been commonly reported. However, serious UTIs have only happened rarely. Fournier’s gangrene has rarely been reported in people taking Steglatro after drug approval.

Symptoms of infection

Symptoms of mild urinary tract infections can include:

Symptoms of more serious UTIs can include:

Symptoms of genital yeast infections can vary from person to person as follows:

  • in men, * symptoms may include:
    • redness, pain, itching, or burning around the head of the penis and under the foreskin
    • difficulty removing the foreskin
  • in women, * symptoms may include:
    • burning, tingling, or pain during sex or urination

Symptoms of Fournier’s gangrene can include:

  • tenderness, pain, swelling, redness, or discoloration of the genitals or perineum
  • fever greater than 100.4 ° F (38 ° C)
  • malaise (generally feeling unwell)

* Sex and gender exist on spectra. The use of the terms “male” and “female” in this article refers to the sex assigned at birth.

What you can do

To help prevent UTIs while taking Steglatro, be sure to drink plenty of water. It will also help prevent dehydration, which is a possible serious side effect of Steglatro. Drinking cranberry juice can also help prevent UTIs. Here are more tips to help prevent UTIs:

  • wiping back and forth after urinating, in women *
  • urinating soon after having sex

To help prevent genital infections while you are taking Steglatro, you can try these measures:

  • Avoid wearing tight underwear, tights, pants, or leggings.
  • Wash your genitals daily with a gentle cleanser.
  • Avoid using scented products on your genitals.
  • Eat yogurt or take lactobacilli supplements to encourage healthy bacteria in your genital area.

If you have symptoms of a mild UTI or genital yeast infection while taking Steglatro, tell your doctor or pharmacist. They can recommend a treatment plan.

However, if you have symptoms of a more serious UTI or Fournier’s gangrene, see your doctor immediately. These infections require urgent treatment with antibiotics. In some cases, they may need to be treated in hospital.

* Sex and gender exist on spectra. The use of the terms “male” and “female” in this article refers to the sex assigned at birth.

Ketoacidosis

Some people taking Steglatro can have a serious side effect called ketoacidosis.

Ketoacidosis occurs when the cells in your body do not receive enough sugar for energy. As a result, they use fat instead of sugar for energy. When this happens, acidic substances called ketones can build up in your blood.

Although not common, ketoacidosis is a medical emergency because it can be life threatening.

Symptoms of ketoacidosis include:

  • dry mouth
  • the thirst
  • nausea and vomiting
  • abdominal pain
  • malaise (generally feeling unwell)
  • weakness or fatigue
  • difficulty in breathing
  • fruity breath

While you are taking Steglatro, you may have a higher risk of ketoacidosis if you:

  • have a disease with fever
  • eating much less than usual due to fasting or discomfort
  • drinking large amounts of alcohol
  • Undergo surgery

What you can do

To help prevent ketoacidosis with Steglatro, tell your doctor immediately if you have a fever or if you eat less than usual. You should also avoid drinking large amounts of alcohol.

If you have any planned surgeries, talk to your doctor about your treatment plan. Your doctor may recommend that you stop Steglatro for a few days before the planned surgery. Then your doctor will tell you when to start taking the medicine again after your surgery.

If you have symptoms of ketoacidosis, stop taking Steglatro and see your doctor immediately. But if your symptoms are severe or life threatening, call 911 or your local emergency number. Ketoacidosis may require treatment in hospital.

Allergic reaction

As with most medicines, some people may have an allergic reaction after taking Steglatro.

Symptoms of a mild allergic reaction can include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under the skin, usually on the eyelids, lips, hands or feet
  • swelling of the tongue, mouth, or throat
  • difficulty in breathing

Call your doctor right away if you have an allergic reaction to Steglatro, as the reaction could get serious. Call 911 or your local emergency number if your symptoms are life-threatening or if you think you have a medical emergency.


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