May 11, 2022

Side Effects, Dosage, Uses & More

Ropinirole is a prescription medication used to treat movement disorders. It works by mimicking dopamine in your brain.

This medication is taken by mouth and is available in immediate-release and extended-release tablets. Timed-release medications are released more slowly into your bloodstream throughout the day, while immediate-release medications work faster.

Ropinirole was previously sold under the brand names Requip and Requip XL. Both brand names have since been discontinued for commercial rather than security reasons. Ropinirole is still available in generic formulas.

Depending on your treatment plan, this medication may be used as part of combination therapy. This means that you would take ropinirole with other medicines as directed by a doctor.

Read on to learn more about ropinirole, including its potential uses and benefits, and possible risks and side effects that you should discuss with a doctor.

Taking ropinirole can cause side effects. Clinical tests have shown mild to severe side effects associated with ropinirole.

It is important to discuss possible side effects with a doctor before taking this medication. If you experience any side effects after taking this medicine, tell the prescribing doctor or a member of your healthcare team.

Common side effects

the The most common side effects associated with ropinirole include:

Mild side effects may go away on their own. But if they are more serious or do not go away, talk to a doctor or pharmacist. Some side effects, such as trouble sleeping and indigestion, can still be experienced during the maintenance phase of taking the drug.

Serious side effects

While drowsiness or sudden drowsiness isn’t always harmful on its own, it can become dangerous if you’re in the middle of activity or operating heavy machinery when it occurs. This could increase your risk of falls or accidents. Some people taking ropinirole have experienced severe drowsiness after 1 year to take this medicine.

Additionally, there are other potentially serious or life-threatening side effects that may warrant an immediate call to 911 or your local emergency services. These side effects and their symptoms may include the following:

  • fainting or loss of consciousness
  • heart rate changes, especially if you have a history of heart disease
  • low blood pressure that leads to falls
  • high fever
  • muscle stiffness

Other serious side effects may be psychiatric in nature. You should contact the doctor who prescribed your medicine if you experience symptoms such as:

  • hallucinations
  • paranoia, or heightened suspicion and distrust of people
  • great confusion
  • aggressive behaviour
  • increased restlessness
  • intense urges, such as those related to gambling, shopping, binge eating, or sex

Ropinirole may also bind to melanin in the skin, according to animal studies. This can possibly increase the risk of melanoma, a serious skin cancer. See your doctor if you notice rapid changes in the size, shape, and color of moles on your skin.

Be sure to follow the doctor’s instructions about taking ropinirole and any other medications. Your dosage may vary.


Ropinirole belongs to a class of medications called dopamine agonists. These have the same effect on your central nervous system as the natural chemical dopamine. Ropinirole is primarily used in the treatment of movement disorders, including Parkinson’s disease and restless leg syndrome.

The body needs dopamine to help control movement. In diseases such as Parkinson’s disease, the cells that produce dopamine die. Ropinirole works by acting in place of the missing dopamine without having to be converted.

Before use

The exact dosage and dosing instructions for ropinirole may depend on the following factors:

  • the condition being treated
  • how serious is the condition
  • your age
  • other medical conditions

Tell your doctor about any side effects you experience after the initial dose and if you have experienced any side effects with other medicines you have taken.


Ropinirole is taken daily by mouth. To act effectively, the drug must be swallowed whole — do not crush or divide the tablets.

You can take ropinirole with or without food. However, taking it with food may help prevent stomach upset.

If you need to stop taking this medicine, a doctor will slowly reduce your dose, usually over the course of 7 days. Do not stop taking ropinirole suddenly or change your dosage without talking to a doctor.

The prescribing physician will provide specific dosing information related to your condition. Below are the general guidelines for this medication.

Parkinson’s disease

For the treatment of Parkinson’s disease, a doctor may prescribe ropinirole Doses of 2 milligrams (mg) daily for 1-2 weeks. Depending on drug response and side effects, the dose may be increased weekly in intervals of 2 mg per day.

The doctor may also initially prescribe immediate-release tablets. They may switch you to extended-release tablets as you respond to the medication. The maximum daily (daily) dose is 24mg.

restless leg syndrome

If you are taking ropinirole for restless legs syndrome, your doctor will prescribe a daily dose of 0.25mg. For best results, take the medication 1-3 hours before bedtime.

Depending on your response to the medication, your doctor may gradually increase your dose at the following intervals:

  • Days 3 to 7: 0.5 mg daily
  • Week 2: 1 mg daily
  • Week 3: 1.5 mg daily
  • Week 4: 2 mg daily
  • Week 5: 2.5 mg daily
  • Week 6: 3 mg daily
  • Week 7: 4 mg daily

In kidney disease

Ropinirole may be initially prescribed in doses of 2mg per day if you have kidney failure. If you are on dialysis, the maximum daily (daily) dose is 18 mg.

How to handle a missed dose

It is important to take ropinirole daily, as prescribed by your doctor. If you miss a dose, the medicine may not work as well or stop working altogether. For this medication to work well, a certain amount must be present in your body at all times.

If you miss a dose, take ropinirole as soon as you remember. However, if you remember a few hours before your next scheduled dose, take only one dose. Never try to make up for it by taking two doses at once. This could lead to dangerous side effects.

Storage and Disposal

Store ropinirole at room temperature, between 68 and 77°F (20 and 25°C). You should also store this medication away from moisture and light. Be sure to keep the tablets in their container and close the lid tightly after each use.

If you need to dispose of unused or unused Ropinirole tablets, ask a doctor or pharmacist, or search for local drug take-back programs. Never throw your medicines in the trash and never flush them down the toilet.

Taking ropinirole can cause side effects, such as allergic reactions.

Allergy Warning

Ropinirole can cause a severe allergic reaction, which can cause symptoms such as:

  • difficulty breathing
  • difficulty swallowing
  • swelling of the tongue, lips, face or throat
  • eruption
  • urticaria

If you develop these symptoms, call 911 or your local emergency services, or go to the nearest emergency room.

It is also important to avoid taking ropinirole if you have ever had an allergic reaction.

Pregnancy and breastfeeding

Discuss with the doctor if you are pregnant or plan to become pregnant. Ropinirole should only be used if the potential benefit justifies the potential risk.

Animal studies of the drug have suggested that when used during pregnancy it can cause birth defects or miscarriage. However, further studies are needed.

Although there have been no studies to show whether ropinirole can harm babies through breast milk, the medicine may decrease lactation.

For children and older adults

Ropinirole has not been confirmed as safe and effective for use in children. under 18.

Dose adjustments may not be necessary in adults 65 and over because the dose should be adjusted according to each person’s response. That said, older people may process drugs more slowly, so more of a drug stays in the body longer, which could increase the risk of side effects.

Ropinirole may interact with the following drugs:

  • Inhibitors and inducers of cytochrome P450 1A2 (CYP1A2), present in several types of drugssuch as fluvoxamine for mental health disorders and certain medications taken for gastrointestinal disorders, sleep disorders and bacterial infections
  • estrogens, including those in birth control pills
  • other dopamine antagonists

Before using ropinirole, tell a doctor about any other prescription drugs, supplements, and herbs you are currently taking. This will help reduce the risk of a possible drug interaction.

Symptoms of a ropinirole overdose may include:

  • dizziness
  • nausea or vomiting
  • to cough
  • excessive sweating
  • Heart palpitations
  • extreme tiredness
  • drowsiness
  • confusion
  • hustle

If you think you have taken too much ropinirole, call your doctor or local poison control center. If your symptoms are severe, call your local emergency services or go to the emergency room immediately.

Although ropinirole can help replace missing dopamine in the treatment of movement disorders, it is not the only option available. Talk to a doctor about all treatment options for your condition. You may also find that one drug works better than others.

Other types of dopamine agonists may include:

  • apomorphine hydrochloride (Kynmobi)
  • apomorphine hydrochloride (Apokyn) injections
  • pramipexole (Mirapex, Mirapex ER)
  • transdermal rotigotine (Neupro)

Ropinirole is a prescription medication that can help treat movement disorders. It is a dopamine agonist that is approved for the treatment of Parkinson’s disease and restless leg syndrome. However, this drug is not approved for pediatric patients.

Drowsiness or sudden drowsiness is one of the most common side effects associated with this medication. It is important to discuss possible side effects with a doctor before use, especially if you are taking other medications or have an underlying medical condition.

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