May 11, 2022

Side Effects, Dosage, Uses & More

Like most medicines, Sinemet can cause mild to severe side effects. The lists below describe some of the more common side effects that Sinemet can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Sinemet. They can also suggest ways to help reduce side effects.

For more information on the possible side effects of Sinemet in older adults, see the ‘Focus on side effects’ section below.

Mild side effects

Here is a short list of some of the mild side effects that Sinemet can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Package Leaflet for Sinemet. prescribing information.

Mild Sinemet side effects that have been reported include:

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects of Sinemet can occur. If you have serious side effects, call your doctor right away. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious Sinemet side effects that have been reported include:

  • depression, which can lead to suicidal thoughts and behaviors
  • extreme fatigue, which may cause you to fall asleep during regular activities, such as driving
  • hyperpyrexia (extreme increase in body temperature) and confusion
  • abnormal thoughts or behaviors, such as:
  • compulsive behaviors and inability to control these urges, such as:
    • excessive gambling or purchases
    • engaging in sexual activity that may pose risks, such as that of infection
  • melanoma (a type of skin cancer)
  • hallucinations (seeing or hearing things that aren’t really there)*
  • dyskinesia (uncontrollable movements)*
  • allergic reaction*

*For more information on this side effect, see the “Side Effects Focus” section below.

SUICIDE PREVENTION

If you think someone is at immediate risk of harming themselves or another person:

  • Dial 911 or your local emergency number.
  • Stay with the person until help arrives.
  • Remove any guns, knives, drugs, or other objects that could cause damage.
  • Listen, but don’t judge, argue, threaten or yell.

If you or someone you know is considering suicide, get help from a crisis or suicide prevention hotline. Try the National Suicide Prevention Lifeline at 800-273-8255.

Focus on side effects

Learn more about some of the side effects Sinemet can cause.

Side effects in the elderly

The side effects of Sinemet in older people are generally the same as those in young adults. But people aged 65 and over are more likely to have certain health problems, such as liver and kidney problems. These conditions can increase the level of Sinemet in your body. And it increases the risk of certain side effects, like hallucinations.*

*For more details on hallucinations with Sinemet, see “Hallucinations” just below.

What might help

If you are 65 or older, talk to your doctor before starting treatment with Sinemet. They will describe the risks and benefits of taking Sinemet and help you decide if the drug is right for you.

Hallucinations/psychotic-like behavior

You may experience hallucinations and psychotic-like behavior with Sinemet.

Hallucinations happen when you see or hear things that aren’t really there. In some cases, you may also taste, smell, or feel things that aren’t there.

If you have hallucinations with Sinemet, you may also have:

You may have a higher risk of hallucinations with Sinemet:

  • right after you start taking the medicine
  • if you have a history of certain mental health problems, such as psychosis
  • if you are 65 or older*

Sinemet can also cause abnormal thinking and behavior including aggressive behavior, restlessness, delusions, paranoia and psychotic-like behavior.

* Older people may have certain health conditions that increase the level of Sinemet in their blood. Or they may be more susceptible to certain side effects. And it could increase their risk of side effects, such as hallucinations.

What might help

Before taking Sinemet, tell your doctor if you have a history of mental disorders. They can advise you if Sinemet is right for you.

If you experience hallucinations while taking Sinemet, tell your doctor. If you have recently started taking the drug, the side effect should disappear within a few days to a few weeks. But your doctor may decide to lower your dose or switch you to another medicine.

Dyskinesia

You may have dyskinesia with Sinemet. It was one of the most common side effects in studies drug.

Dyskinesias are uncontrollable movements that can affect your whole body. Examples include:

  • contractions
  • fidget
  • restlessness
  • sway
  • head bobbing

You may have a higher risk of dyskinesia with Sinemet if you are also taking tricyclic antidepressants (TCAs), such as amitriptyline.

What might help

Before taking Sinemet, tell your doctor about all other medicines you are taking. They can advise you if any of them could increase your risk of dyskinesia with Sinemet.

If you experience symptoms of dyskinesia while taking Sinemet, tell your doctor. They may decrease your dose or recommend ways to manage this side effect.

Allergic reaction

Some people may have an allergic reaction to Sinemet. It is not known if an allergic reaction has been reported in clinical studies with Sinemet, but it can still happen.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Sinemet. But if you think you have a medical emergency, call 911 or your local emergency number.


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