You should discuss some important points with your doctor before starting treatment with Lynparza. Be sure to tell them about your general health, any medical conditions you may have, and any medications you take.
Taking medicine with certain vaccines, foods, and others can affect how the medicine works. These effects are called interactions.
Before taking Lynparza, talk with your doctor about all the medicines you are taking, including prescription and over-the-counter medicines. You should also describe any vitamins, herbs or supplements you use. Your doctor or pharmacist can tell you about any interactions these may cause with Lynparza.
For more information on drug-condition interactions, see the “Warnings” section below.
Interactions with Medications or Supplements
Several types of medicines can interact with Lynparza and affect the levels in your body. This may increase your risk of side effects or prevent Lynparza from working. Because of these interactions, doctors usually do not prescribe Lynparza with the following:
This list does not contain all types of drugs that may interact with Lynparza. Your doctor or pharmacist can tell you more about these interactions and any other interactions that may occur with Lynparza.
It is recommended that you do not eat grapefruit or Seville oranges or drink juice from these fruits while taking Lynparza. This may increase your risk of side effects.
Lynparza may not be right for you if you have certain medical conditions. These are known as drug-condition interactions. Other factors may also determine whether Lynparza is a good treatment option for your condition. Discuss your medical history with your doctor before taking this medication. Factors to consider include those listed below.
- Kidney problems. Be sure to speak with your doctor if you have kidney problems, such as chronic kidney disease, before starting Lynparza. You may need to take a lower dose of the medicine. But if your kidney problems are severe or you have end-stage kidney disease, your doctor will likely recommend a different treatment than Lynparza.
- Lung or breathing problems. Lynparza may cause side effects affecting your lungs, including shortness of breath or pneumonitis (inflammation of the lungs). If you have lung or breathing problems, such as chronic obstructive pulmonary disease (COPD), you may be at increased risk for these side effects. And these could then make your respiratory symptoms worse. Your doctor can help you determine if Lynparza is safe for you.
- Allergic reaction. If you’ve had an allergic reaction to Lynparza or any of its ingredients, your doctor probably won’t prescribe it for you. Ask them about other treatments that might be better options.
Lynparza and alcohol
There are no known interactions between taking Lynparza and drinking alcohol. But drinking alcohol can cause many of the same side effects as Lynparza. Taking them together can increase your risk of diarrhea, fatigue (low energy), nausea, and vomiting.
If you drink alcohol, discuss with your doctor how much, if any, you can safely consume while taking Lynparza.
Pregnancy and breastfeeding
Your doctor will probably advise you not to take Lynparza during pregnancy. They may recommend other treatment options for your condition instead.
If you can become pregnant, your doctor may order a pregnancy test to check that it is negative before prescribing Lynparza. They will also likely recommend that you use effective birth control while taking the medicine and for at least 6 months after your last dose.
It is not known if Lynparza is present in breast milk. But due to the risk of serious side effects in a breastfed child, it is recommended not to breastfeed during treatment. You should also wait at least 1 month after your last dose of Lynparza to start breastfeeding.