May 11, 2022

Side Effects, Uses, Dosage and More

Like most medicines, Kyprolis can cause mild or severe side effects. The lists below describe some of the more common side effects that Kyprolis can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Kyprolis. They can also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Kyprolis can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Kyprolis package leaflet. prescribing information.

Mild Kyprolis side effects that have been reported include:

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious Kyprolis side effects can occur, but they are not common. If you have serious side effects from Kyprolis, call your doctor right away. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious Kyprolis side effects that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some of the side effects that Kyprolis can cause.

Heart problems

With Kyprolis you may experience cardiotoxicity (damage to the heart muscles). This can lead to new or worsening heart problems, including heart failure and heart attack.

Heart problems were a less common side effect in studies of Kyprolis. In rare cases, heart problems with the drug can be fatal.

Symptoms of heart problems can vary depending on the exact condition you have. But possible symptoms include chest pain, leg swelling and difficulty breathing.

Certain factors may increase your risk of heart problems with Krypolis, such as:

  • have heart failure or a recent heart attack
  • be at least 75 years old
  • have heart disease

What might help

Before starting your treatment with Kyprolis, tell your doctor if you have heart problems. Also tell them if you have any other factors listed above that could increase your risk of heart problems.

During your treatment with Kyprolis, your doctor will watch for symptoms of new or worsening heart problems. Tell them right away if you have any symptoms of heart problems.

If you have this side effect, your doctor may stop your treatment until your heart problems are resolved. Or they may prescribe you a drug other than Kyprolis.

Blood clots

Some people may get blood clots with Kyprolis. In studies, this side effect was rare in people who took Kyprolis alone. But blood clots were more common in people who took the medicine with other medicines, such as dexamethasone and lenalidomide (Revlimid).

You may also have a higher risk of blood clots if you take Kyprolis with a hormonal contraceptive, such as birth control pills.

Possible symptoms of blood clots may include:

  • swelling of the arms or legs
  • leg cramps
  • warmth, redness, or discoloration in the area around the clot
  • difficulty breathing

What might help

Tell your doctor about all other medicines you are taking before starting treatment with Kyprolis. They can determine if these drugs may increase your risk of blood clots.

If you take Krypolis with dexamethasone or lenalidomide, your doctor may prescribe treatments to help prevent blood clots from forming. For example, you can take a blood thinner like warfarin (Jantoven).

If you have blood clot symptoms with Kyprolis, call your doctor right away. But if your symptoms seem severe or life-threatening, call 911 or your local emergency number.

Allergic reaction

Some people may have an allergic reaction to Kyprolis.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Kyprolis. But if you think you have a medical emergency, call 911 or your local emergency number.


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