August 13, 2022

Side Effects, Uses & More

Like most medicines, tacrolimus IR oral capsules can cause mild or severe side effects. The lists below describe some of the more common side effects that tacrolimus IR oral capsules can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of tacrolimus IR oral capsules. They can also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects tacrolimus IR oral capsules can cause. To learn about other mild side effects, talk to your doctor or pharmacist, or read tacrolimus IR oral capsules. prescribing information.

Mild side effects of tacrolimus IR oral capsules that have been reported include:

Mild side effects of many medications may disappear within days or weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious side effects from tacrolimus IR oral capsules can occur, but they are not common. If you experience serious side effects with tacrolimus IR oral capsules, call your doctor right away. However, if you think you have a medical emergency, you should call 911 or your local emergency number.

Serious side effects of tacrolimus IR oral capsules that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn about some of the side effects tacrolimus IR oral capsules can cause.

Boxed warnings

Tacrolimus IR oral capsules have boxed warnings. A framed warning is a serious warning from the Food and Drug Administration (FDA). Boxed warnings of the drug are described below.

Serious infections. Taking tacrolimus may increase your risk of serious infections. These can include bacterial, viral and fungal infections. You may also be at risk of parasitic infections when taking tacrolimus.

If you have symptoms of infection while taking tacrolimus, tell your doctor straight away. Symptoms vary depending on the type of infection, but can include:

  • cough
  • fatigue (lack of energy)
  • fever or chills
  • sweat
  • muscle aches
  • redness, warmth, or pain affecting your skin

Cancer. Tacrolimus can also cause certain types of cancer. These could include skin cancer and cancer of the lymphatic system called lymphoma. The risk of cancer with tacrolimus may increase with higher doses of the drug or treatment that lasts longer.

What might help

Your doctor will ask you if you have any symptoms of infection while taking tacrolimus. But if you develop symptoms, tell them right away.

Your doctor can adjust your treatment plan to reduce your risk of infection. And they will treat any infections you have, as needed.

If you have an increased risk of skin cancer with tacrolimus, your doctor will check to see if your skin changes. Also talk to your doctor about what to look for when monitoring your skin for cancer. Also, limit your exposure time to sunlight and ultraviolet light. And be sure to wear protective clothing and sunscreen with a high sun protection factor (SPF).

Your doctor will assess the risks and benefits of tacrolimus treatment for you. He will prescribe the most appropriate dose for you and for the duration that is safe for you.

If you are concerned about tacrolimus side effects, talk to your doctor. Do not stop taking tacrolimus or any other medicine without talking to your doctor. And don’t change your dose without talking to your doctor first.

Nephrotoxicity

Tacrolimus can damage your kidneys, which is also called nephrotoxicity. Some people may have long-term kidney damage from tacrolimus.

Taking certain medicines with tacrolimus may increase your risk of kidney damage. These drugs include some drugs used to treat HIV.

Symptoms of toxicity from kidney damage may include:

  • difficult or painful urination
  • increased urge to urinate

What might help

During treatment with tacrolimus, your doctor will monitor your kidney function. If you develop kidney damage while taking tacrolimus, your doctor may lower your dose of the drug.

While taking tacrolimus, you should see your doctor often and have any tests needed to monitor your kidneys.

Neurotoxicity

Tacrolimus can also cause brain damage, sometimes called neurotoxicity. Some conditions affecting your brain that may be caused by tacrolimus include:

Sometimes people can develop brain damage if the level of tacrolimus in their blood is too high.

Symptoms of brain injury toxicity may include:

What might help

Your doctor will monitor you for any changes in your mental state and neurological health.

If you develop brain problems with tacrolimus, your doctor may lower your dose of the drug. In some situations, your doctor may tell you to stop taking tacrolimus.

Your doctor will also check the level of tacrolimus in your blood. If your levels are above the desired range, your doctor may reduce your medication dose.

If you feel tacrolimus is affecting your brain, do not stop taking it without first talking to your doctor. And don’t adjust your dose without talking to your doctor.

Allergic reaction

Some people may have an allergic reaction to tacrolimus IR oral capsules.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • urticaria
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Additionally, some people who are allergic to tacrolimus may develop acute respiratory distress syndrome (ARDS). ARDS is a life-threatening disease that affects your ability to breathe.

Call your doctor right away if you have an allergic reaction to tacrolimus IR oral capsules. But if you think you have a medical emergency, call 911 or your local emergency number.


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