May 11, 2022

Side Effects, Uses, Price, Dosage and More

Before you start taking Caplyta, it is important to talk to your doctor about any other medicines you are taking. You should also tell your doctor about any medical conditions you have. Telling your doctor about these factors will help them determine if Caplyta may be a safe and effective treatment option for you.

interactions

Taking medicine with certain vaccines, foods, and other things can affect how the medicine works. These effects are called interactions.

Before taking Caplyta, be sure to tell your doctor about all medications you are taking, including prescription and over-the-counter medications. Also describe any vitamins, herbs or supplements you use. Your doctor or pharmacist can tell you about any interactions these may cause with Caplyta.

Interactions with Medications or Supplements

Caplyta can interact with several types of medications. These drugs include:

  • certain antiepileptic drugs, such as phenytoin (Dilantin) and carbamazepine (Tegretol)
  • certain antibiotics, such as ciprofloxacin (Cipro), erythromycin (Eryc) and clarithromycin (Biaxin XL)
  • certain antifungal medicines, such as fluconazole (Diflucan), itraconazole (Sporanox), and voriconazole (Vfend)
  • certain heart medications, such as diltiazem (Cardizem) and verapamil (Verelan)
  • pioglitazone (Actos), a medicine for diabetes
  • corticosteroid prednisone (Rayos)
  • certain HIV medications, such as fosamprenavir (Lexiva), ritonavir (Norvir), nelfinavir (Viracept), efavirenz (Sustiva), and etravirine (Intelence)
  • the organ transplant drug cyclosporine (Gengraf, Neoral, Sandimmune)
  • the antidepressant medications fluvoxamine (Luvox) and nefazodone
  • the anti-tuberculosis drug rifampicin (Rimactane)
  • the lung drug bosentan (Tracleer)
  • narcolepsy drugs modafinil (Provigil) and armodafinil (Nuvigil)
  • the medicine aprepitant for nausea and vomiting (Emend)

This list does not contain all types of drugs that may interact with Caplyta. Your doctor or pharmacist can tell you more about these interactions and any other interactions that may occur with Caplyta.

Other exchanges

You should avoid consuming grapefruit or grapefruit juice while taking Caplyta. Grapefruit may reduce how your liver breaks down Caplyta, which may cause you to have more side effects.

Additionally, Caplyta may also interact with the herbal supplement containing St. John’s Wort. If you are taking this supplement, talk to your doctor before starting Caplyta.

Boxed warnings

Caplyte at framed warnings. These are serious warnings from the Food and Drug Administration (FDA) about the effects of drugs that can be dangerous.

Boxed warnings include:

  • Risk of suicidal thoughts or actions. Antidepressants can increase the risk of suicidal thoughts or behaviors in children and young adults. This includes Caplyta, which is used to treat depression related to bipolar disorder. Because Caplyta is only approved to treat certain conditions in adults, this risk may affect adults between the ages of 18 and 24 taking this medicine.
  • Risk of death in older people with dementia-related psychosis. Antipsychotic medicines such as Caplyta may increase the risk of death in adults aged 65 or over with dementia-related psychosis.

For more information on these boxed warnings, see “What are the side effects of Caplyta?” » section above.

Other warnings

Caplyta may not be right for you if you have certain medical conditions or other factors that affect your health. Discuss your medical history with your doctor before taking Caplyta. Factors to consider include those listed below.

Diabetes. Caplyta can cause your blood sugar levels to rise, which can lead to diabetes. If you already have diabetes, taking Caplyta may make your condition worse. If you have diabetes, talk to your doctor about the best treatment option for you. Your doctor may recommend more frequent monitoring of your blood sugar or suggest another treatment option.

Allergic reaction. If you’ve had an allergic reaction to Caplyta or any of its ingredients, your doctor probably won’t prescribe Caplyta for you. Ask your doctor what other medications are better options for you.

High triglycerides or high cholesterol. If you have high triglyceride or cholesterol levels, taking Caplyta may further increase these levels. Your doctor may suggest that you monitor your cholesterol and triglyceride levels more frequently while taking Caplyta. Or they may recommend a different treatment option for you.

Low white blood cell count. Caplyta can lower the levels of white blood cells in your body. If you already have a low white blood cell count, taking Caplyta may make your condition worse. A low white blood cell count can lead to infections that can become serious.

If you have a condition that causes a low white blood cell count, talk to your doctor about the best treatment option for your schizophrenia or depression related to bipolar disorder. Your doctor may monitor your white blood cell count more frequently during treatment. Or they may recommend a different treatment option for you.

Seizures. Caplyta may increase your risk of seizures. If you already have a seizure disorder, taking Caplyta may further increase your risk of seizures. Because of this risk, your doctor may monitor you more frequently to watch for changes in seizure activity. Or they may recommend a different treatment option for you.

Low or high blood pressure. Caplyta may affect your blood pressure. This can cause your blood pressure to drop too low, which can lead to dizziness or even fainting. Also, this medication may increase your risk of heart problems.

These risks increase if you already have high or low blood pressure before you start taking Caplyta. Your doctor may recommend that you monitor your blood pressure throughout treatment with Caplyta. If your blood pressure gets too high or too low, they may recommend medications to raise or lower your blood pressure.

Liver problems. If you have certain liver problems, Caplyta may not be safe to take. Before you start taking this medication, tell your doctor about any liver problems you have. They may monitor your liver function more closely or suggest that you try a different medication for your condition.

Heart problems, including strokes. Caplyta may increase your risk of certain heart problems. Also, this medication may increase the risk of stroke in some people with dementia-related psychosis. Be sure to tell your doctor about any illnesses you have that affect your heart or blood vessels. Your doctor will tell you if Caplyta may be a safe treatment option for you.

Difficulty regulating body temperature. This medication may prevent your body from regulating its temperature. You can become overheated or even dehydrated. If you have any conditions that may increase your risk of dehydration or overheating, talk to your doctor before starting Caplyta. This will help them determine if this medication may be a safe treatment option for you.

Caplyte and alcohol

There are no known interactions between Caplyta and alcohol. But drinking alcohol while taking this medication may increase your risk of certain side effects. Examples include nausea, vomiting, and drowsiness.

Also, drinking alcohol while taking Caplyta may affect your ability to drive a car.

Discuss with your doctor how much alcohol, if any, you can safely drink while taking Caplyta.

Pregnancy and breastfeeding

It is not known whether Caplyta may be a safe treatment option during pregnancy or while breastfeeding.

Studies show that newborn babies of women* taking Caplyta during the third trimester of pregnancy may have uncontrollable muscle movements or withdrawal symptoms. But there are also risks of not treating schizophrenia or bipolar depression during pregnancy.

There is a Pregnancy Exposure Registry for people taking atypical antipsychotics such as Caplyta during pregnancy. The registry collects data that can help determine the effects a drug may have on pregnant women and a developing fetus. To join the Pregnancy Registry, call 866-961-2388 or visit This site.

It is not known if Caplyta is safe to take while breastfeeding. At this time, it is not known if the drug can pass into breast milk or what effects it may have on a nursing child.

Discuss with your doctor if you are pregnant, breastfeeding, or planning to become pregnant or breastfeeding before you start taking Caplyta. They can discuss the benefits and risks of taking this medication during this time.

* In this article, we use the term “female” to refer to the sex assigned to someone at birth. For more information on the difference between sex and gender, check out this article.


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