June 23, 2022

Use for hepatitis C, side effects, dosage, etc.

Some important things to discuss with your doctor when considering treatment with Sovaldi include your general health and any medical conditions you may have.


Taking medicine with certain vaccines, foods, and other things can affect how the medicine works. These effects are called interactions.

Before taking Sovaldi, be sure to tell your doctor about all medications you are taking, including prescription and over-the-counter medications. Also describe any vitamins, herbs or supplements you use. Your doctor or pharmacist can tell you about any interactions these may cause with Sovaldi.

Interactions with Medications or Supplements

Sovaldi may interact with several types of medications, including:

  • St. John’s worta herbal supplement
  • the anti-HIV drug tipranavir (Aptivus)*
  • certain antiepileptic medicines, such as:
    • phenytoin (Dilantin, Phenytek)
    • carbamazepine (Carbatrol, Epitol, Tegretol)
    • oxcarbazepine (Oxtellar XR, Trileptal)
    • phenobarbital
  • amiodarone (Nexterone, Pacerone), a medicine for heart rhythm
  • certain antibiotics, such as:
    • rifampicin (Rifadin, Rimactane)
    • rifabutin (Mycobutin)
    • rifapentine (Priftin)

This list does not contain all types of drugs that may interact with Sovaldi. Your doctor or pharmacist can tell you more about these interactions and any other interactions that may occur while using Sovaldi.

* Tipranavir is used with another anti-HIV medicine called ritonavir (Norvir). However, there is no known interaction between Sovaldi and ritonavir.

Framed warning

Sovaldi has framed warning for the risk of hepatitis B virus (HBV) reactivation. This is a serious warning from the Food and Drug Administration (FDA) about the effects of drugs that can be dangerous.

If you have ever had HBV, Sovaldi may reactivate (burst) the virus in your body.

For more information, see the “Boxed warning” section at the beginning of this article.

Other warnings

Sovaldi may not be right for you if you have certain medical conditions or other factors that affect your health. Talk to your doctor about your medical history before taking Sovaldi. Factors to consider include those listed below.

  • Kidney problems. It is not known if Sovaldi is safe or effective for people with serious kidney disease, such as kidney failure. If you have severe kidney disease, ask your doctor if Sovaldi is the right medicine for you. They may prescribe a different drug.
  • Liver problems, including liver transplant. It is not known if Sovaldi is safe or effective for people with certain liver problems. Talk to your doctor if you have liver problems other than hepatitis C. For example, if you have had a liver transplant before or if you have cirrhosis (scarring of the liver) that is causing symptoms. Your doctor may choose a different medicine to treat your condition. And if you have liver cancer and are expecting a liver transplant, they may also give you a different dose of Sovaldi than is usually prescribed.
  • Allergic reaction. If you’ve had an allergic reaction to Sovaldi or any of its ingredients, your doctor probably won’t prescribe Sovaldi for you. Ask them what other medications are better options for you.

Sovaldi and alcohol

There are no known interactions between Sovaldi and alcohol. But drinking alcohol can increase the risk of cirrhosis (scarring of the liver) in people with the hepatitis C virus (HCV). (Sovaldi is used to treat HCV.) Because of this risk, your doctor may recommend that you avoid alcohol while taking Sovaldi.

If you drink alcohol, talk to your doctor before taking Sovaldi.

Pregnancy and breastfeeding

It is not known if Sovaldi is safe to use during pregnancy. But it is important to note that Sovaldi is taken with ribavirin, which is not safe to take during pregnancy. This is because ribavirin can cause fetal harm or abortion.

If you are sexually active and you or your partner could become pregnant, tell your doctor about your birth control needs while taking Sovaldi.

According HCV Guidelines from the American Association for the Study of Liver Diseases, doctors generally suggest waiting until after pregnancy to treat HCV. If you are pregnant or planning to become pregnant, talk to your doctor before taking Sovaldi.

It is also not known if it is safe to use Sovaldi while breastfeeding. If you are breastfeeding or plan to breastfeed, talk to your doctor before taking this medication.

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