May 11, 2022

Uses, dosage, side effects, cost, etc.

Like most medicines, Lokelma can cause mild or severe side effects. The lists below describe some of the more common side effects that Lokelma can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Lokelma. They can also suggest ways to help reduce side effects.

Mild side effects

Swelling is the only mild side effect reported in studies. For more details on swelling, see “Focus on side effects” below. And to learn more about side effects in studies, you can see Lokelma’s article prescribing information.

Mild side effects of many medications may disappear within days or weeks. But if they become bothersome, talk to your doctor or pharmacist.

Serious side effects

Serious Lokelma side effects can occur, but they are not common. If you have serious side effects from Lokelma, call your doctor right away. If you think you have a medical emergency, call 911 or your local emergency number.

Serious Lokelma side effects that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some side effects Lokelma can cause.


Swelling, also called edema, can happen with Lokelma. In studies, the swelling was generally mild to moderate. It may be more common in people taking higher doses of Lokelma.

Lokelma contains a form of sodium (salt) as the active ingredient (the ingredient that makes the medicine work). Too much sodium in your body can cause your body to retain more fluid, which can lead to swelling. It’s unclear how much sodium your body can retain while you’re taking Lokelma.

What might help

If you get swelling while taking Lokelma, talk to your doctor. They may recommend that you limit sodium in your diet.

Another way to reduce swelling is to take another medicine that releases water from your body. Your doctor may prescribe this type of medicine, called a diuretic.

If you have certain heart or kidney conditions, or currently need to limit the amount of sodium in your diet, your doctor may monitor your swelling while you are taking Lokelma.

Low potassium

Lokelma is used to treat hyperkalemia (high potassium), and sometimes you may develop hypokalemia (low potassium) as a side effect.

You might only experience symptoms of hypokalemia if your potassium levels drop below a certain level. Your doctor can tell you what is considered low potassium.

Symptoms of low potassium can include:

Severe hypokalemia can be life-threatening.

If you are having hemodialysis (a treatment that filters waste from your blood) while taking Lokelma, you are more likely to have severe hypokalaemia. See “What should be considered before taking Lokelma?” below for more details.

What might help

Your doctor may change your dose of Lokelma or tell you to stop taking it if your potassium levels get too low. They will monitor your potassium level with blood tests during your treatment. Be sure to tell your doctor immediately about any symptoms of low potassium.

Allergic reaction

Some people may have an allergic reaction to Lokelma.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Lokelma. But if you think you have a medical emergency, call 911 or your local emergency number.

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